Abstract:

BACKGROUND: As the leptin has close relationship with the incidence of osteoporosis, so it may relates to the incidence of femoral head necrosis.
OBJECTIVE: To study the correlation between serum leptin, serum lipid and osteonecrosis of femoral head.
METHODS: From June 2011 to March 2012, 65 patients with nontraumatic osteonecrosis of the femoral head were selected from Department of Orthopedics, the Third Hospital of Hebei Medical University, and 60 healthy adults were selected as controls. The levels of serum leptin, total cholesterol, triglyceride, low and medium-density lipoprotein, high-density lipoprotein and apolipoprotein A1 and B were measured.
RESULTS AND CONCLUSION: In osteonecrosis of the femoral head group, the levels of serum leptin, total cholesterol, triglyceride, low and medium-density lipoprotein and apolipoprotein B were significantly higher than those in the control group (P < 0.05), while the levels of high-density lipoprotein and apolipoprotein A1 were significantly lower than those in the control group (P < 0.05). The level of serum leptin in the female patients was higher than that in the male patients (P < 0.05). The level of serum leptin was positively correlated with serum lipid. ①The increasing of the serum leptin level in patients with nontraumatic osteonecrosis of the femoral head plays a role in the process of the disease. ②The serum leptin concentrations are positively correlated with the development of nontraumatic osteonecrosis of the femoral head.