Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (52): 9828-9835.doi: 10.3969/j.issn.2095-4344.2012.52.027

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Expression and application of cytokines in osteoarthritis

Ren Hong-ge1, Cui Feng-de2   

  1. 1First Department of Orthopedic Surgery, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China
    2Department of Immunology and Pathogenic Biology, Yanbian University Health Science Center, Yanji 133002, Jilin Province, China
  • Received:2012-08-25 Revised:2012-09-15 Online:2012-12-23 Published:2012-12-23
  • Contact: Cui Feng-de, Professor, Doctoral supervisor, Department of Immunology and Pathogenic Biology， Yanbian University Healthy Science Center, Yanji 133002, Jilin Province, China fdcui@ybu.edu.cn
  • About author:Ren Hong-ge☆, Doctor, Associate chief physician, First Department of Orthopedic Surgery, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China renhg196@sina.com

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Abstract:

BACKGROUND: Osteoarthritis is a kind of normal disease, results from a complex system of interacting mechanical, biological, biochemical, molecular and enzymatic feedback loops. Cytokines are closely related to the pathological process of osteoarthritis.
OBJECTIVE: To summarize the research progress of cytokines in the occurring and development of osteoarthritis.
METHODS: An online search of Wanfang database and PubMed database was performed by the first author for articles published between 2000 and 2012 that related to cytokines and osteoarthritis.
RESULTS AND CONCLUSION: A total of 69 articles on the application of cytokines in osteoarthritis were included. Cytokines play an important role in the occurring and development process of osteoarthritis; cytokines can promote the degradation of osteoarthritic cartilage, synovitis and resorption of subchondral bone. Some cytokines also have an inhibitory effect in the development of osteoarthritis. Matrix metalloproteinase is related to catabolism; transforming growth factor, bone morphogenic protein, insulin-like growth factor, fibroblast growth factor and vascular endothelial growth factor are related to anabolism. Inflammatory factors which affect the function of joint cells include interleukin, chemokine and tumor necrosis factor. But the mechanisms of cytokines in the occurring and the development of osteoarthritis and clinical application of cytokines need further study.

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