Abstract:

BACKGROUND: Early experiments have shown that quercetin chitosan membrane has obvious therapeutic effect on oral ulcer
OBJECTIVE: To verify the anti-inflammatory and analgesic effects of quercetin chitosan composite solution．
METHODS: SD rats or Kunming mice were randomly divided into four groups: control group, chitosan group, quercetin chitosan composite solution group and Bingpeng San group. ①Experiment of rat foot swelling induced by carrageenin: The feet in each group of rats were immersed in normal saline, chitosan solution, quercetin chitosan solution and Bingpeng San solution. And then the rats were administered with carrageenin foot injection. ②Experiment of rat ear swelling induced by croton oil: The ears of rats in each group were treated with the above drugs, and then given the croton oil in ears. ③Experiment of rat pain induced by hot plate: Foot sole of rats in each group was smeared with the above drugs and given hot plate stimulation experiments before and after application.
RESULTS AND CONCLUSION: Compared with the control group, the quercetin chitosan composite solution group significantly inhibited the ear and foot swelling of rats as well as foot pain (P < 0.05, P < 0.01).Besides, pain threshold and analgesic pain killer was increased (P < 0.05, P < 0.01). What’s more, the effect in the quercetin chitosan composite solution group was better than that in the Bingpeng San group and chitosan group. These results suggest that quercetin chitosan composite solution has obvious anti-inflammatory and analgesic eff