Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (41): 7772-7776.doi: 10.3969/j.issn.2095-4344.2012.41.034

Previous Articles     Next Articles

Neural differentiation capacity and potential clinical application of adipose-derived mesenchymal stem cells

Han Chao1, 2, Song Lin1, Zou Wei2, Liu Jing1   

  1. 1Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
    2College of Life Science, Liaoning Normal University, Dalian 116011, Liaoning Province, China
  • Received:2012-02-09 Revised:2012-03-25 Online:2012-10-07 Published:2012-10-07
  • Contact: Liu Jing, M.D., Professor, Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
  • About author:Han Chao★, Studying for master’s degree, Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China hanchao0427@163.com

Abstract:

BACKGROUND: It has been recently confirmed that adipose-derived stem cells have the characteristics of the mesenchymal stem cells (MSC) residing in bone marrow. They have the same cell surface markers and are capable of differentiating into the same cell types, including osteoblasts, chondrocytes, myoblasts, adipocytes, and neuron-like cells.
OBJECTIVE: To review the biological characteristics of adipose-derived mesenchymal stem cells and their clinical application for treatment of somatic nervous system diseases.
METHODS: A computer-based online retrieval of PubMed database was performed to search the papers describing neural differentiation capacity of adipose-derived mesenchymal stem cells and their clinical application for treatment of nervous system diseases published during January 1989 to January 2012 using the key words mesenchymal stem cell, nervous system disease, stem cell therapy. A total of 733 papers were retrieved, and 26 were included for final analysis.
RESULTS AND CONCLUSION: Adipose tissue is ubiquitous in human body, can be easily harvested and is of high purity, with high activity and strong amplification, which make adipose-derived mesenchymal stem cells to become the ideal seed cells for clinical application in regeneration medicine. Recent studies have pointed out that adipose-derived mesenchymal stem cells greatly promote the functional recovery of injured nerve. Nevertheless, the mechanism underlying curative effects of adipose-derived mesenchymal stem cells are still in the exploratory stage, and the efficacy and safety of adipose-derived mesenchymal stem cells in treatment of nervous system disease need to be investigated by a large number of clinical case data. All these restrict the clinical application of adipose-derived mesenchymal stem cells.

CLC Number: