Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (40): 7572-7579.doi: 10.3969/j.issn.2095-4344.2012.40.029

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Detection of cytomegalovirus infection after renal transplantation

Jin Chun-ming   

  1. Department of Laboratory, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang 157000, Heilongjiang Province, China
  • Received:2012-06-18 Revised:2012-07-25 Online:2012-09-30 Published:2012-09-30
  • About author:Jin Chun-ming, Associate chief examiner, Department of Laboratory, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang 157000, Heilongjiang Province, China jcm-1234@163.com

Abstract:

BACKGROUND: Due to the decreasing cellular immunity and humoral immunity after renal transplantation, the patients may suffer various types of infection easily, and cytomegalovirus infection is more common with high morbidity and mortality. The early and accurate detection is conducive to guide clinical treatment.
OBJECTIVE: To multi-level explore and analyze the articles on the detection of cytomegalovirus infection after renal transplantation.
METHODS: A computer-based search was performed in CNKI database from January 2002 to December 2011 for the articles on the detection of cytomegalovirus infection after renal transplantation. The key words were “renal transplantation, cytomegalovirus, BK virus” in Chinese and English. Cytomegalovirus was the main pathogens for the infection after renal transplantation, and was closely related with the occurrence of pneumonia and hepatitis after renal transplantation, retinitis and the acute and chronic rejection after renal transplantation.
RESULTS AND CONCLUSION: The method for the detection of cytomegalovirus infection after renal transplantation is continuously improved and there are various detection methods. To data, there is no ideal way to early and accurate detect the active cytomegalovirus infection. The method for diagnosing the cytomegalovirus infection after renal transplantation is mainly the combination of serological testing, fluorescence immunoassay mark detection, detection of antigen-antibody and genetic testing. Detection of the cytomegalovirus late antigen (pp65) is developed rapidly, which improve the specificity and sensitivity of detection of cytomegalovirus infection, and provide an important reference for the clinical diagnosis and preventive treatment.

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