Abstract:

BACKGROUND: Acute rejection after renal transplantation is common in clinic, and the immunosuppressive agents can promote and facilitate the improvement of the quality of the renal transplantation, while the reasonable application of immunosuppressive agents is important for the patients with renal transplantation and has become the important factors that affecting the survival rate of patients.
OBJECTIVE: To multi-level analyze the literatures on the acute rejection after renal transplantation and the immunosuppressive agents.
METHODS: A computer-based search was performed on Web of Science database for the literatures on the acute rejection after renal transplantation and the immunosuppressive agents from 202 to 2011, the key words were “renal transplantation, acute rejection, immunosuppressive agents”. The acute rejection after renal transplantation was classified to study the types of the immunosuppressive agents after renal transplantation and to analyze the characteristics of various immunosuppressive agents.
RESULTS AND CONCLUSION: A total of 6 105 literatures on the acute rejection after renal transplantation and the immunosuppressive agents between 2002 and 2011 were screened out from the Web of Science database, and the number of the literature is in an increasing trend. Transplantation Proceedings journal mainly publishes the research on the acute rejection after renal transplantation and the immunosuppressive agents. And the majority of related studies are from the United States, followed by Germany. Among the top 10 literatures arranged according to the cite frequency from high to low, four literatures from The New England Journal of Medicine. In the past 10 years, the number of the included literatures in China is the No. 9, and a total of 238 literatures have been published, among the literatures, there are 17 literatures are supported by the National Natural Science Foundation.