Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (30): 5586-5590.doi: 10.3969/j.issn.2095-4344.2012.30.016

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Effect of prostaglandin E2 on the acute pain of the patients with simple closed long bone fracture

Ding Yang-yang, Ding Cheng-biao, Zhang Jian-xiang, Tang Jian, Peng Lei   

  1. Third Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
  • Received:2012-04-01 Revised:2012-05-14 Online:2012-07-22 Published:2012-07-22
  • Contact: Tang Jian, Chief physician, Professor, Master’s supervisor, Third Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China 282261913@qq.com
  • About author:Ding Yang-yang★, Studying for master’s degree, Third Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China 282261913@qq.com

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Abstract:

BACKGROUND: The accumulation of prostaglandin E2 can cause the pain and increase the sensitivity of pain producing substance, such as the bradykinin, and decrease the pain threshold of the nerve root and cause the pain.
OBJECTIVE: To observe the effect of prostaglandin E2 in the acute pain caused by acute fracture.
METHODS: The patients with acute pain symptoms caused by simple acute closed long bone fracture received the analgesic treatment by intravenous injection of non-steroidal anti-inflammatory analgesics drug (intravenous flurbiprofen axetil injection). The pain visual analogous scale score was used to measure the pain scores before and after treatment, and the prostaglandins levels of the blood samples were measured.
RESULTS AND CONCLUSION: The visual analog scale score and the level of prostaglandin E2 at 30 minutes before medication and 6 hours after medication were significantly higher than those at 2 hours after medication (P < 0.05). It confirmes that prostaglandin E2 plays an important role in the treatment of acute pain caused by simple acute closed long bone fracture, active use of analgesic drugs that inhibit the prostaglandin levels can effectively control the pain.

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