Abstract:

BACKGROUND: Chitosan combined with collagen can be more effective to stop the bleeding.
OBJECTIVE: To assess the material properties and biocompatibility of collagen/chitosan hemostatic dressing materials in surgical wounds.
METHODS: A computer-based search was performed for articles addressing biological dressings, collagen/chitosan hemostatic materials in wounds or during wound hemostasis published from January 2000 to June 2010. The keywords were “biomaterial, hemostatic material, gauze, collagen/chitosan, biocompatibility” in Chinese and “biomaterial, hemostatic material, bioresorbable material, hemostasis effect, hemostatic mechanism” in English.
RESULTS AND CONCLUSION: Chitosan has unique biological properties that are characterized to have a broad-spectrum antibacterial activity, to promote epithelial cell growth and hemostasis, promote wound healing, and have a good biodegradability and tissue compatibility, which can be used for treatment of fingertip injury and granulation wound. Chitosan can be applied to prepare wound dressings, absorbable sutures, hemostatic materials, anti-blocking agent, drug delivery and tissue engineering scaffolds for wound treatment under field conditions.