Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (29): 5423-5427.doi: 10.3969/j.issn.2095-4344.2012.29.021

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Synthesis of poly(p-dioxanone)

Cui Man-man, Gong Lian-sheng   

  1. National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha 410008, Hunan Province, China
  • Received:2012-05-05 Revised:2012-05-15 Online:2012-07-15 Published:2012-07-15
  • Contact: Gong Lian-sheng, Chief physician, Professor, National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha 410008, Hunan Province, China gls8280@yahoo. com.cn
  • About author:Cui Man-man★, Master, National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha 410008, Hunan Province, China manmusiccui@yahoo.com

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Abstract:

BACKGROUND: Poly(p-dioxanone), as an aliphatic polyester, has its special characters comparing with other aliphatic polyesters. Except for its ultimate biodegradability due to the existence of ester bonds in polymer chains, the unique ether bonds endue it with good flexibility.
OBJECTIVE: To explore the optimal conditions for chemical synthesis of poly(p-dioxanone).
METHODS: Poly(p-dioxanone) was synthesized by ring-opening polymerization of p-dioxanone using stannous octoate as catalyst in bulk at 80, 100 and 140 ℃ for 10, 20 and 30 hours. Temperature and reaction time effects on the synthesis of homopolymers were observed.
RESULTS AND CONCLUSION: The aliphatic homopolymer poly(p-dioxanone) is successfully synthesized by ring-opening polymerization of p-dioxanone using stannous octoate as catalyst in bulk. Based on the monomer conversion rate, the optimal conditions for the synthesis of homopolymers are 100 ℃ for reaction temperature and 20 hours for reaction time.

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