Thrombopoietin improves platelet recovery after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia: an assessment of safety and efficacy

doi:10.3969/j.issn.2095-4344.1835

Abstract

Abstract:

BACKGROUND: Studies have shown that the use of thrombopoietin after allogeneic hematopoietic stem cell transplantation has a certain role in hematopoietic regulation and hematopoietic reconstitution, providing a theoretical basis for clinical application.
OBJECTIVE: To analyze the clinical efficacy and safety of thrombopietin in the treatment of severe aplastic anemia after hematopoietic stem cell transplantation.
METHODS: Fifty patients receiving allogeneic hematopoietic stem cell transplantation from January 2012 to January 2017 including 28 males and 22 females with the mean age of 27.8 (16-48) years were enrolled. Patients received 300 U/kg thrombopietin (treatment group, n=25) subcutaneously, which began at 7 days after transplantation, or were only treated with symptomatic treatment (control group, n=25). Time node of platelet implantation in two groups of patients ≥ 20×10⁹/L, 50×10⁹/L, and 100×10⁹/L and median Infusion times of platelet were compared between two groups. The study protocol was approved by the Ethics Committee of Army General Hospital, and enrolled patients signed informed consent prior to the inception of the trial.
RESULTS AND CONCLUSION: The median time of platelet implantation ≥ 20×10⁹/L, 50×10⁹/L, and 100×10⁹/L was 16.2, 19.3, and 30.2 days in the treatment group and 18.8, 25.8, and 38.5 days in the control group, respectively. The time of platelet implantation time in the treatment group was 2.6, 6.5, and 8.3 days earlier than that in the control group. The median number of irradiated platelet implantation was 6.8 times in the treatment group and 9.5 times in the control group. There was a significant difference between the two groups (P < 0.05). All the patients were followed up to July 2017, and the disease-free survival rates were 80% in the treatment group and 72% in the control group. These findings indicate that thrombopietin can promote platelet implantation and recovery after allogeneic hematopoietic stem cell transplantation, and is well tolerated, which is worthy of further clinical application.

Key words: severe aplastic anemia, allogeneic hematopoietic stem cell transplantation, thrombopoietin, platelet implantation, hematopoietic regulation, hematopoietic reconstitution

CLC Number:

Guo Zhi, Ren Hua, Ji Yong, Chen Liping, Chen Lina, Liu Xuanyong, Zheng Shanshan, Liu Xiaodong, Chen Huiren. Thrombopoietin improves platelet recovery after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia: an assessment of safety and efficacy [J]. Chinese Journal of Tissue Engineering Research, 2019, 23(33): 5269-5274.

Figures/Tables 2

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