Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (31): 5726-5730.doi: 10.3969/j.issn.1673-8225.2011.31.006

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Effects of omega-3 fish oil emulsion on changes in serum cytokines after liver transplantation

Jiang Tao, Wang Xuan, Yang Ai-zhen, Lu Lei, Zhang Dong-hua, Zhang Rong-sheng   

  1. Liver Transplantation Center of Nanjing Military Command, the 81 Hospital of Chinese PLA, Nanjing  210002, Jiangsu Province, China
  • Received:2011-05-21 Revised:2011-06-29 Online:2011-07-30 Published:2011-07-30
  • About author:Jiang Tao★, Master, Attending physician, Liver Transplantation Center of Nanjing Military Command, the 81 Hospital of Chinese PLA, Nanjing 210002, Jiangsu Province, China jiangsht@126.com
  • Supported by:

    a General Program of Nanjing Military Command of Chinese PLA, No. 08MA050*

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Abstract:

BACKGROUND: Omega-3 fish oil emulsion can adjust systemic inflammatory response after liver transplantation.
OBJECTIVE: To investigate the effects of omega-3 fish oil emulsion on the changes of cytokines and the prognosis of patients undergoing liver transplantation.
METHODS: All 36 orthotopic liver transplantation patients were prospectively randomized into two groups: experimental and control. After liver transplantation, two group patients received isocaloric and isonitrogenous nutritional support and the same immunosuppressive regimen. From day 2 after liver transplantation, the experimental group patients received omega-3 fish oil emulsion for successive 6 days while the control group patients did not.
RESULTS AND CONCLUSION: Compared with the control group, on days 5, 8 after liver transplantation, interleukin (IL)-1β, IL-2, IL-6, tumor necrosis factor (TNF)-α, prostaglandin E2, and leucotriene B4 were downregulated to different degrees, IL-4, IL-10, TNF-β and leukotriene were upregulated to different degrees in the experimental group. On day 8 after liver transplantation, the ratio of IL-6/IL-10 was significantly decreased and the ratio of IL-10/ TNF-α was significantly increased (P < 0.01). There was no significant difference in perioperative mortality and acute rejection incidence between experimental and control groups. However,
The postoperative ICU stay time and hospital stay time were significantly shorter in the experimental group than in the control group (P < 0.05). These results showed that additional omega-3 fish oil emulsion in liver transplantation patients can effectively decline the levels of proinflammatory cytokines and retrieve the extra inflammatory response, modulate the balance of pro-/anti-inflammation, and improve prognosis.

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