Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5063-5067.doi: 10.3969/j.issn.1673-8225.2011.27.027

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Expression of stromal cell-derived factor-1 after articular cartilage injury

Lu Ding-gui1, Wei Qing-jun1, Li Qiao-chuan2, Wei Ji-hua1, Xiao Shi-hui1, Li Wei-an1   

  1. 1Department of Trauma, 2Stem Cell Transplantation Centre, the First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-03-02 Revised:2011-06-09 Online:2011-07-02 Published:2011-07-02
  • Contact: Wei Qing-jun, Doctor, Associate professor, Department of Trauma, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China weiqingjungxnn@163.com
  • About author:Lu Ding-gui★, Studying for master’s degree, Department of Trauma, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China ludinggui@163.com
  • Supported by:

    the Scientific Research Foundation for the Returned Overseas Chinese Scholars in Guangxi Zhuang Autonomous Region, No. 305696*

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Abstract:

BACKGROUND: Studies have demonstrated that stromal cell-derived factor-1 (SDF-1) can influence the migration and aggregation of bone marrow mesenchymal stem cells (BMSCs).
OBJECTIVE: To observe the expression of SDF-1 at lesion regions at different time after cartilage injury and to investigate the correlation between SDF-1 expression and BMSCs migration.
METHODS: Rabbits models of articular cartilage injury were established. Focal osteochondral lesions were collected 2, 5, 7, 10, 14 and 28 days after injury. The influence of SDF-1 expression on the migration of BMSCs and chondrocytes was observed.
RESULTS AND CONCLUSION: SDF-1 expression was significantly increased and peaked at the seventh day (P < 0.05). BMSCs migrated toward articular cartilage injury tissue, while they were significantly inhibited by the inhibitor of CXCL4. SDF-1 expression increases in the early phase after articular cartilage injury, and plays an important role in chemoattracting MSCs to injured lesions.

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