Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5021-5025.doi: 10.3969/j.issn.1673-8225.2011.27.018

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Vein transplantation of olfactory ensheathing cells for spinal cord injury

Wei Kai-bin1, Liu Yu-liang1, Liu Hong2, Lü Xin-gang3, Zhang Wen-zheng1, Li Jun1   

  1. 1Department of Orthopedics, 2Department of Nuring, Taian City Central Hospital, Taian  271000, Shandong Province, China; 3Laiwu Central Hospital of Xinwen Mining Bureau, Laiwu  271100, Shandong Province, China
  • Received:2010-11-27 Revised:2011-02-08 Online:2011-07-02 Published:2011-07-02
  • About author:Wei Kai-bin☆, Doctor, Chief physician, Department of Orthopedics, Taian City Central Hospital, Taian 271000, Shandong Province, China wkb1966@163.com
  • Supported by:

    Outstanding Middle-age and Young Scientist Award Foundation of Shandong Province, No. 2007BS03035*

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Abstract:

BACKGROUND: Olfactory ensheathing cell transplantation is a better theray for spinal cord injury, and it becomes one of the most promising treatment methods. Local transplantation is applied currently, with the disadvantages of complex operation, large trauma, repeated transplantation. Looking for a simple and effective way for cell transplantation becomes a hotspot for scholars from various countries.
OBJECTIVE: To investigate the effect and possibility of transplantation of olfactory ensheathing cells for treatment of spinal cord injury.
METHODS: Wistar rats with T10 spinal cord hemisection were divided into 4 groups: intramedullary local transplantation group (A), vein transplantation group (B), D/F12 transplantation group (C) and control group (D). The functional recovery of rats with spinal cord injury was observed with combined behavioral score at different phases. The tissue sections of each group were made at 5 and 10 weeks postoperatively to observe the axon regeneration and the survival of olfactory ensheathing cells.
RESULTS AND CONCLUSION: The experiment showed that the rats transplanted with OECs at injured site and through the vein had more improvement in functional recovery and histological changes than the other two groups. The effect between A group and B group had not significant difference. The method of treating spinal cord injury by transplanting OECs via the vein not only simplifies the operation and avoids many complications but also has good curative effect similar to local transplantation.

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