Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5011-5015.doi: 10.3969/j.issn.1673-8225.2011.27.016

Previous Articles     Next Articles

Influence of autologous bone marrow mononuclear cells transplantation on SDF-1-CXCR4

Zhang Yun-qiang, Xu Ai-guo, Qi Xiang-qian   

  1. Cardiology Clinical Institute of Tianjin Medical University, TEDA International Cardiology and Vascular Hospital, Tianjin  300457, China
  • Received:2011-03-11 Revised:2011-05-20 Online:2011-07-02 Published:2011-07-02
  • About author:Zhang Yun-qiang☆, Doctor, Attending physician, Cardiology Clinical Institute of Tianjin Medical University, TEDA International Cardiology and Vascular Hospital, Tianjin 300457, China zhangyqby@126.com

PDF

416

Abstract:

BACKGROUND: Recently, the SDF-1-CXCR4 mRNA expression and the effect after stem cell transplantation have obtained more attention.
OBJECTIVE: To observe the changes of SDF-1 mRNA and CXCR4 mRNA expression in the myocardium after bone marrow mononuclear cells (BM-MNCs) transplantation.
METHODS: Sixteen mongrel dogs were randomly divided into the graft group and the control group. Each of dog was implanted a permanent pacemaker for rapid right ventricular pacing for 3 to 4 weeks. CM-DiI 1abled BM-MNCs or saline were transplanted into the myocardium via epicardium injection.
RESULTS AND CONCLUSION: After 3-4 weeks of rapid pacing, the cardiac function of the dogs in both two groups significantly decreased in hemodynamic and in ultrasound parameters. The mRNA levels of SDF-1 and CXCR4 were higher in the graft group than those in the control group (P < 0.01). Autologous BM-MNCs transplantation improves the mRNA level of SDF-1 and CXCR4.

CLC Number: