Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (23): 4363-4366.doi: 10.3969/j.issn.1673-8225.2011.23.042

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Umbilical cord mesenchymal stem cells transplantation for newly-onset type 1 diabetes

Yu Wen-long1, Gao Hong2, Yu Xiao-long1, Wang Li2, Yan Sheng-li1, Wang Yan-gang1,2   

  1. 1Department of Endocrine, 2Chinese-American Research Center for Stem Cells, Affiliated Hospital of Qingdao University Medical College, Qingdao  266003, Shandong Province, China
  • Received:2010-03-19 Revised:2010-05-24 Online:2011-06-04 Published:2011-06-04
  • Contact: Wang Yan-gang, Doctor, Chief physician, Doctoral supervisor, Department of Endocrine, Chinese-American Research Center for Stem Cells, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China wangyg1966@yahoo.com.cn
  • About author:Yu Wen-long★, Studying for master’s degree, Department of Endocrine, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China wenlongyuwenlong@126.com

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Abstract:

BACKGROUND: Autologous hematopoietic stem cells transplantation can enhance function of beta cells of islet and prolong time independent of insulin.
OBJECTIVE: To observe the clinical efficacy of human umbilical cord mesenchymal stem cells (hUCMSCs) transplantation in treatment of newly-onset type 1 diabetes.
METHODS: A total of 12 patients with newly-onset type 1 diabetes mellitus (less than 3 months) were selected. Six cases were treated by hUCMSCs transplantation and insulin, and the other 6 were treated by insulin alone. Before and 9 months after transplantation, fasting and postprandial blood glucose, insulin dosage, C peptide, HbA1c changes and adverse events were measured.
RESULTS AND CONCLUSION: Patients were followed up for 9 months. Fasting blood glucose, HbA1c and C peptide levels were significantly improved in stem cell therapy group compared with control group. In addition to significantly reduced C peptide levels, other indexes remained unchanged in control group. Results showed that hUCMSCs transplantation has positive effects on treatment of newly-onset type l diabetes.

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