Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (23): 4355-4358.doi: 10.3969/j.issn.1673-8225.2011.23.040

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Correlation of peripheral blood CD34-positive cells with creatine kinase MB, N-terminal pro-B-type natriuretic peptide, and left ventricular ejection fraction in patients with acute myocardial infarction

Gao Hai-ying1, Qu Peng2   

  1. 1Department of Internal Medicine, 2Department of Cardiology, the Second Affiliated Hospital of Dalian Medical University, Dalian  116027, Liaoning Province, China
  • Received:2011-02-25 Revised:2011-03-27 Online:2011-06-04 Published:2011-06-04
  • About author:Gao Hai-ying★, Master, Attending physician, Department of Internal Medicine, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027,Liaoning Province, China Gaohaiying77@yahoo.com.cn

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Abstract:

BACKGROUND: Some studies had showed the potential of self-mobilization of CD34 positive stem cells in peripheral blood after acute myocardial infarction. Population remain poorly known about the correlation between the number of CD34 positive stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI).
OBJECTIVE: To assess the spontaneous expression of CD34-positive cells after AMI and its relation to creatine kinase MB (CK-MB), NT-proBNP and LVEF. 
METHODS: The CD34-positive mononuclear cells in the peripheral blood of experimental patients were measured on days 2, 3, 4, 5, 7, 30, 90 and 120 after onset of AMI by flow cytometry. At the corresponding time the venous blood of control group, non-coronary heart disease people, also were collected. In experimental group, their myocardiac enzyme and cardiac troponin I were detected and NT-proBNP and echocardiography (UCG) were recorded.
RESULTS AND CONCLUSION: ①Flow cytometry revealed that percentage of peripheral blood CD34-positive mononuclear cells significantly increased on day 3 after AMI onset, reaching the peak level on day 4 and decreased gradually to the base line on day 90. ②The CD34-positive mononuclear cell was positively correlated with the LVEF levels and negatively correlated with NT-proBNP levels. The findings indicated that AMI is followed by enhanced spontaneous mobilization of CD34-positive cells. The peripheral blood CD34-positive mononuclear cells may improve cardiac function of ischemic heart disease and reduce the incidence rate of heart failure after AMI.

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