Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (23): 4295-4298.doi: 10.3969/j.issn.1673-8225.2011.23.026

Previous Articles     Next Articles

Granulocyte colony-stimulating factor mobilizes peripheral blood CD34+ cells in patients with type 2 diabetes mellitus

Dou Li-dong1, Cui Xiao-lan2, Chen Jian-he1, Wang Li-mei1, Wang Yi-zhong1   

  1. 1Department of Hematology and Endocrinology, Aerospace Clinical Medical College of Peking University, Beijing  100049, China
    2Pharmacology Laboratory, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing  100700, China
  • Received:2011-03-15 Revised:2011-04-25 Online:2011-06-04 Published:2011-06-04
  • Contact: Wang Yi-zhong, Doctor, Chief physician, Master’s supervisor, Department of Hematology and Endocrinology, Aerospace Clinical Medical College of Peking University, Beijing 100049, China vipwyz@126.com
  • About author:Dou Li-dong★, Studying for master’s degree, Department of Hematology and Endocrinology, Aerospace Clinical Medical College of Peking University, Beijing 100049, China
  • Supported by:

    Scientific Research Fund of China Aerospace Science and Industry Group, No. 2009-JKBZ-003*

PDF

264

Abstract:

BACKGROUND: The number of mobilized peripheral blood CD34+ cells significantly decreases in type 2 diabetes mellitus patients compared with normal subjects.
OBJECTIVE: To investigate the changes of mobilized peripheral blood CD34+ cells in type 2 diabetes mellitus patients.
METHODS: A total of 234 patients with type 2 diabetes mellitus were divided into five categories according to disease duration, newly diagnosed type 2 diabetes (≤1 year) and diabetes duration (1-5, 5-10, 10-15, ≥15 years). CD34+ cells were mobilized with granulocyte colony-stimulating factor. Five days later, the number of peripheral blood CD34+ cells was detected with flow cytometry. Its relationship with disease duration, blood lipids and uric acid was analyzed by person-related analysis and multiple regression analysis.
RESULTS AND CONCLUSION: The number of mobilized peripheral blood CD34+ cells was associated with the triacylglycerol (r=-0.202, P=0.002), the apoprotein-B (r=-0.276, P=0.000), and the uric acid (r=-0.297, P=0.000). Statistical analysis found that, the number of mobilized peripheral blood CD34+ cells decreased with development of diabetes mellitus.

CLC Number: