Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (23): 4257-4261.doi: 10.3969/j.issn.1673-8225.2011.23.018

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Risk factors for Epstein-barr virus reactivation after allogeneic hematopoietic stem cells transplantation

Cao Xing-hui, Fan Zhi-ping, Jiang Qian-li, Zhao Jie, Yu Guo-pan, Wei Qi, Sun Jing, Liu Qi-fa   

  1. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2011-04-08 Revised:2011-05-10 Online:2011-06-04 Published:2011-06-04
  • Contact: Fan Zhi-ping, Master, Lecturer, Attending physician, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China fanzp@fimmun.com Correspondence to: Liu Qi-fa, Master, Professor, Chief physician, Doctoral supervisor, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China liuqifa@fimmu.com
  • About author:Cao Xing-hui★, Master, Physician, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China caoxinghui24wu@163.com
  • Supported by:

    the National High-Tech Research and Development Plan of China, No. 2006AA02Z4A0*; the National Natural Science Foundation of China, No. 30971300*

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Abstract:

BACKGROUND: Epstein-barr virus (EBV) reactivation following allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cause deadly post-transplant lymphoproliferative disorders and other EBV-associated diseases. At present, a complete diagnosis and treatment system about EBV reactivation and EBV-related disease has not been established in China.
OBJECTIVE: To investigate prospectively the incidence of EBV reactivation and risk factors following allo-HSCT.
METHODS: 129 patients receiving allo-HSCT were included. EBV-DNA in peripheral blood were detected by real-time PCR; Kaplan-Meier model was used for analyzing cumulative incidence of EBV reactivation, and binary logistic regression model was used for analyzing risk factors of EBV reactivation.
RESULTS AND CONCLUSION: EBV reactivation and EBV associated disease have high incidence rate after allo-HSCT. Risk factors for EBV reactivation include HLA mismatched, use of antithymocyte globulin, grade III-IV acute graft-versus-host disease and age less than or equal to 20 years old.

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