Abstract:

BACKGROUND: Continuous blood purification, also known as renal replacement therapy, is an important technique in recent years. It has been an essential way for treatment of acute renal failure, multiple organ failure and various acute and critical patients.
OBJECTIVE: To evaluate the effect of continuous blood purification (CBP) on acute renal failure after liver transplantation.
METHODS: We retrospectively analyzed the data of 10 patients complicated with acute renal failure after liver transplantation received CBP therapy using BM-25 CBP machine. Treatment pattern adopted continuous veno-venous hemofiltration (CVVH) and anterior/posterior dilution method. Ordinary heparin or low molecular heparin or non heparin was used as anticoagulant. Treatment time was 5-30 days. Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), blood urea nitrogen (BUN), serum creatinine (SCr), potassium chloride (K+), and base excess (BE) were observed.
RESULTS AND CONCLUSION: In the ten cases, eight cases survived, and the survival rate from ICU was 80.0%. During CBP treatment, vital signs were stable, hemodynamic markers improved, and anasarca gradually relieved. Twenty-four hours after CBP, HR and CVP decreased obviously as MAP increased. Electrolyte and blood gas analysis ameliorated obviously. BUN, SCr, and K+ decreased. There was significant difference between the data before and after treatment (P < 0.05). It is indicated that CBP can obviously improve the prognosis of patients with acute renal failure after liver transplantation.