Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (18): 3255-3258.doi: 10.3969/j.issn.1673-8225.2011.18.007

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Protective effects of penequinine hydrochloride on acute lung injury induced by orthotopic liver transplantation

Si Jian-luo1, Song Shao-tuan1, Chang Sheng2   

  1. 1Department of Anesthesiology, First Affiliated Hospital, Henan University of Science and Technology, Luoyang  471003, Henan Province, China
    2Institute of Organic Transplantation, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan  430030, Hubei Province, China
  • Received:2010-11-20 Revised:2011-01-24 Online:2011-04-30 Published:2011-04-30
  • About author:Si Jian-luo★, Master, Attending physician, Department of Anesthesiology, First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, Henan Province, China jianluo_si@sina.com

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Abstract:

BACKGROUND: Penequinine hydrochloride can alleviate inflammatory response and protect against cell injury, but therapeutic effects were uncertainty on acute lung injury after orthotopic liver transplantation.
OBJECTIVE: To evaluate protective efficacy of intravenous penequinine hydrochloride on acute lung injury after orthotopic liver transplantation.
METHODS: Thirty-five patients with acute lung injury after orthotopic liver transplantation were randomly assigned to 2 groups: treatment group (n=17) and control group (n=18). On the base of routine comprehensive therapy, the patients received intravenous infusion with 0.05 mg/kg penequinine hydrochloride once a day for 3 days in the treatment group or with normal saline of same volume in the control group. Plasma interleukin (IL)-8, and IL-10 were measured and index of oxygenation was calculated before and 24, 72 hours after the treatment. Length of mechanical ventilation was recorded.
RESULTS AND CONCLUSION: Compared with the control group, the level of plasma IL-8 decreased significantly in the treatment group at 24 and 72 hours after the treatment, but the level of plasma IL-10 in the treatment group was significantly higher than that in the control group at the same time (P < 0.05). In the treatment group, the patients’ index of oxygenation was higher and length of mechanical ventilation was shorter than that in the control group (P < 0.05). These findings show that penequinine hydrochloride can regulate the level of inflammatory factors in patients with acute lung injury after orthotopic liver transplantation, improve arterial oxygenation and shorten the length of mechanical ventilation.

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