Abstract:

BACKGROUND: Molecular structure of ion exchange resin contains activated groups which can be ionized, it can react with ionic drugs so that the bad smell of drugs is covered up.
OBJECTIVE: To study the ion exchange equilibrium characteristics, kinetics and thermodynamics of tilidine hydrochloride onto Amberlite IRP-69.
METHODS: The tilidine-resin complex was prepared by batch ion exchange method. The ion exchange equilibrium characteristics and kinetics were determined.
RESULTS AND CONCLUSION: Within the temperature range of 293, 303, 313 K, the exchange-adsorption isothermal equation, the Freundlich equation and the Langmuir equation could give perfect fitting for the ion exchange behavior of tilidine hydrochloride onto Amberlite IRP-69, the kinetics of ion exchange is a first-order kinetic equation. Thermodynamic parameters of ion-exchange of tilidine hydrochloride onto Amberlite IRP-69 (ΔH > 0, ΔS > 0) indicated that the ion exchange is endothermic, the temperature rise is beneficial for reaction, and entropy increases; free energy change (ΔG < 0) indicated that the reaction is spontaneous. The equilibrium exchange-adsorption of initial concentration of 5 g/L tilidine hydrochloride on Amberlite IRP-69 was 751.88 g/L. The drug-resin complex can be prepared at room temperature, by continuous stirring 2 hours using certain concentration of tilidine hydrochloride and certain amount of Amberlite IRP-69 as the carrier, and then to develop related products.