Abstract:

BACKGROUND: The common method of preparing poly(l-lactic acid) (PLLA)/hydroxyapatite (HA) composite scaffold includes cold-press method, granule filter method, heat partition method. But there are many respects that can not meet requirements in the interfacial combination, degradation rate, intensity of the materials.
OBJECTIVE: To prepare a PLLA/HA composite nanofiber scaffold.
METHODS: PLLA/HA composite nanofiber scaffold was prepared by electrospinning method. The structure and morphology were studied by scanning electron microscopy. The degradation in PBS was observed in vitro.
RESULTS AND CONCLUSION: There was chemical bonding between HA nanoparticles and PLLA/base, the nanoparticles increased the fiber diameter and the surface roughness, this structure will be conducive to cell extension and reproduction in fiber membrane. HA inhibits the selfcatalys during the PLLA degradation, and slows down the degradation rates of PLLA. The PLLA/HA composite scaffold prepared by electrospinning technique may be potentially applied in tissue engineering scaffolds.