Abstract:

OBJECTIVE: To summarize the influence of serum inflammatory factors on the restenosis after coronary artery stent implantation.
METHODS: Using “coronary artery disease, coronary artery stent implantation, inflammation mediated, scaffold” as the key words, Chinese Journal Full-text database and Medline database were searched from 2001 to 2010. The involved subjects were coronary atherosclerotic heart disease patients who require stenting; confirmed by coronary angiography, these patients were diagnosed as coronary heart disease; there was no limitation in the age, gender, race and region of the patients, and they agreed to coronary stent implantation; detection index was the expression of inflammatory factors. Cases with infectious diseases, bleeding disorders, leukemia, severe liver disease, severe renal insufficiency and cancer are ruled out. A total of 23 literatures were chiefly investigated.
RESULTS: After stent implantation, sCD40L concentration increases along with serum soluble intercellular adhesion molecule-1 concentrations increase. Serum soluble intercellular adhesion molecule-1 and matrix metalloproteinase-9 levels were elevated following stent implantation, and the expressions of adhesion factor serum soluble intercellular adhesion molecule-1 and matrix metalloproteinase 9 were up-regulated; serum interleukin 18 levels and C-reactive protein levels were significantly influenced.
CONCLUSION: In the process of stent implantation, the balloon dilation, stenting and a series of extruded plaque factors contribute to the release of inflammatory factors, increase serum levels of inflammatory factors. Coronary vascular remodeling and reperfusion after vascular injury also promote the increase, and the raising range is associated with coronary artery disease.