Abstract:

BACKGROUND: The key research of bone tissue engineering scaffolds is selecting the appropriate materials for surface modification, targeting to the surface modification of matrix scaffold materials, improving the cell adhesion on the surface of materials, and promoting cell proliferation.
OBJECTIVE: To overview application of bone tissue engineering scaffold materials and scaffold surface modification materials, as well as the modification method or means.
METHODS: A computer-based online search of PubMed database and Wanfang database from 1995 to 2010 was performed by the first author for articles related to use of tissue engineering scaffolds and surface modification.
RESULTS AND CONCLUSION: The roles of osteoblasts and scaffolds depend on the material surface properties, local morphology, surface energy or chemical energy, etc. These surface characteristics determine how to adsorb to the material surface, cell positioning and cell functional behavior. Therefore, the complexity of biomaterials and cell-biomaterial surface interactions determine the importance of surface modification of biological scaffolds. Ideal surface modification should take into account the surface topology, specific identification, hydrophilic and hydrophobic balance, protein adsorption, thus obtaining functionalized new tissue. Currently, the most widely used material for surface modification is collagen I, future research will focus on complementary roles of a variety of composite materials for surface modification, as well as gene therapy and the development of nano-materials, becomes a hot issue in the field of bone tissue engineering study.