Abstract:

BACKGROUND: Recent studies indicate that polydioxanone (PDO) has excellent biodegradability, bioabsorbability and biocompatibility, and it is widely used as tissue repair materials and scaffold materials in medical fields. However, the immunological reaction and mechanism evaluations in vivo need further investigation, so as to better understand the role of these materials in immune system.
OBJECTIVE: To summarize and analyze the degradation characteristics of PDO and its clinical application progress.
METHODS: A computer-based search of PubMed database and CNKI database (2000-01/2010-06) was performed using “polydioxanone, absorbable” in English and “polydioxanone” in Chinese as the key words. A total of 176 articles on the PDO clinical application were selected, including 39 Chinese and 137 English. The earlier published, repeated and similar studies were excluded, finally 25 articles were included in accordance with the criteria.
RESULTS AND CONCLUSION: PDO, one kind of aliphatic polyesters, has excellent biodegradability, bioabsorbability and biocompatibility, and it also has good flexibility. So PDO is the ideal material for surgical suture. It is also used for laminates, tissue repair, electrospun cardiovascular graft and so on. PDO has a wide application prospect in clinical application.