Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (3): 515-518.doi: 10.3969/j.issn.1673-8225.2011.03.033

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Factors affecting the function of drug-loaded microspheres in artificial bone

Li Chao, Fang Tao-lin, Dong Jian   

  1. Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai   200032, China
  • Received:2010-08-02 Revised:2010-08-31 Online:2011-01-15 Published:2011-01-15
  • Contact: Dong Jian, Doctoral supervisor, Professor, Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai 200032, China dong.jian@zs-hospital.sh.cn
  • About author:Li Chao☆, Studying for doctoral degree, Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai 200032, China 0457034@fudan.edu.cn
  • Supported by:

     Sub-project of the National Key Basic Research Program of China (973 Project), No. 2009CB930002*; the National High-Tech Research and Development Program of China (863 Project), No. 2007AA03Z313*; the National Natural Science Foundation of China, No. 30970718*; Shanghai Municipal Outstanding Academic Leaders Program, No. 07XD14006*

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Abstract:

BACKGROUND: As carriers of growth factors or genes, microspheres made with artificial biodegradable materials have been used in bone tissue engineering by many researchers. But the effect of these microspheres on bone defects repair is different, and depends on many factors.
OBJECTIVE: To discuss the factors that affect the function of drug loaded microspheres in bone defect repair, and to lay a foundation for further effective application of drug loaded microspheres.  
METHODS: A computer-based online search of PubMed (1999-01/2010-04) and CNKI (1999-01/2010-04) was performed for related articles with the keywords “gene or growth factor, nanosphere or microsphere, bone”. Thirty studies about application of growth factors- or genes-loaded microspheres were included.
RESULTS AND CONCLUSION: The effect of the drug loaded microspheres is closely related to their material and diameter, surface modification, types of drug loaded and the method of these microspheres combine with artificial bone scaffold. But these factors have not been researched thoroughly and controlled well. Controlling these factors well and ensuring the effective application of drug loaded microspheres in bone tissue engineering need more research from all aspects.

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