Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (3): 507-510.doi: 10.3969/j.issn.1673-8225.2011.03.031

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Green chemical synthesis of poly(lactic acid) based biodegradable polymers

Xu Wen-shu1, Luo Xiang-lin1,2   

  1. 1College of Polymer Science and Engineering, 2State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu   610065, Sichuan Province, China
  • Received:2010-06-25 Revised:2010-08-30 Online:2011-01-15 Published:2011-01-15
  • Contact: Luo Xiang-lin, Doctor, Doctoral supervisor, 1College of Polymer Science and Engineering, 2State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China luoxl_scu@126.com
  • About author:Xu Wen-shu★, Studying for master’s degree, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China xuwenshu2003@163.com
  • Supported by:

    the National Natural Science Foundation of China, No.50873065*

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Abstract:

BACKGROUND: Poly(lactic acid) has excellent biocompatibility and biodegradability, thus it has been widely used in many biomedical fields, such as drug delayed release, surgical suture, tissue engineering scaffold and bone substitutes. Routine synthesis requires the use of solvent, showing low production efficacy and high cost.
OBJECTIVE: Non-solvent green chemical synthesis of poly(lactic acid) based biodegradable materials via direct condensation polymerization and chain extension in melt state were reviewed.
METHODS: A computer-based online search of SCI-Expanded database (1995-01/2010-06) and China Academic Journal Network Publishing Database was performed for related articles with the key words of “poly (lactic acid), diisocyanate” in English and in Chinese. A total of 130 articles regarding the lactic acid polycondensation/diisocyanate chain extension in melt state, including 39 Chinese papers and 91 English ones. Articles with duplicated content and poor experimental results were eliminated, finally 32 articles met the criteria were included.
RESULTS AND CONCLUSION: The biodegradable polylactic acid-based polyurethane materials with different molecular weights and properties can be prepared by lactic acid melt polycondensation/diisocyanate melt chain extension with green chemical method using non-solvent, through changing the type and proportion of isocyanates and prepolymers, it is expected to be practically applied in biomedical fields and daily life.

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