Abstract:

BACKGROUND: The drug-eluting stent (DES) can obviously decrease restenosis rate, but permanent polymer coating impedes the process of vascular endothelial and promotes restenosis, cause many complications such as late thrombosis at the same time of the inhibition of vascular smooth muscle cells proliferation.
OBJECTIVE: To investigate the long-term outcomes and safety after homemade biodegradable DES implantation for patients with coronary artery disease and diabetes mellitus, and compare with bare-metal stents.
METHODS: A total of 136 consecutive patients of coronary artery disease and type-2 diabetes mellitus, receiving homemade biodegradable DES (EXCELTM) implantation following percutaneous coronary angioplasty were studied as DES group; A total of 87 patients with coronary artery disease and type-2 diabetes mellitus treated with bare-metal stents were included as control group. All patients were identified and followed up at least 12 months. The differences of major adverse cardiovascular events were recorded and the patients were rechecked undergoing quantitative coronary angiography.
RESULTS AND CONCLUSION: A total 129 patients in DES group and 83 patients in control group accomplished follow-up at a mean time of (13.5±3.5) months. There were 8 patients and 12 patients in DES group and control group appeared major adverse cardiovascular events with significant difference between the two groups (P=0.045), the rate of target vessel revascularization and repeated angina were higher control group than in BMS group (P < 0.05). The late loss index and restenosis rate with DES were lower when underwent quantitative coronary angiograph follow-up (P < 0.05). The restenosis and major adverse cardiovascular events were reduced by homemade biodegradable DES in coronary heart disease patients with diabetic mellitus, and DES is safe and effective with improved long-termed prognosis.