Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (3): 483-486.doi: 10.3969/j.issn.1673-8225.2011.03.025

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Safety evaluation of bone matrix gelatin with autologous peripheral blood stem cells to repair bone defects

Zhang Xiao-zhou, Zou San-ming, Feng Hua-ming, Huang Du, Kang Zhao-li   

  1. Department of Orthopaedics, Central Hospital of Xiaogan, Tongji Medical College of Huazhong University of Science and Technology, Xiaogan   432000, Hubei Province, China
  • Received:2010-08-09 Revised:2010-09-15 Online:2011-01-15 Published:2011-01-15
  • About author:Zhang Xiao-zhou★, Studying for master’s degree, Associate chief physician, Department of Orthopaedics, Central Hospital of Xiaogan, Tongji Medical College of Huazhong University of Science and Technology, Xiaogan 432000, Hubei Province, China 723174002@qq.com
  • Supported by:

     Science and Technology Program of Hubei Provincial Health Bureau, No. JXIC36*

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Abstract:

BACKGROUND: Animal experiments confirmed that the immunological rejection of bone matrix gelatin (BMG) is small after transplantation and BMG can promote cartilage and bone formation in the early stage.
OBJECTIVE: To study the feasibility of repairing segmental bone defects by autologous peripheral blood stem cells (APBSC)/BMG.
METHODS: The patients with bone defect were divided into 2 groups in accordance with the principle of voluntary. APBSC/BMG group: APBSC/BMG was installed in the bone ends, BMG group: BMG was installed in the bone ends. In addition, external and internal fixations were performed. The positive and lateral X-ray films of the bone defect were taken after surgery.
RESULTS AND CONCLUSION: In APBSC/BMG group, a great amount of new irregular bone fibrous tissues, cartilage, bone cells, bone tissues and bone trabeculae are on the surface of fracture end, with medullary cavity formed. In BMG group, a great amount of fibrous tissues, a less of new irregular bone fibrous tissues and skeletal muscles were seen on the surface of fracture, accompanied by multinucleated giant cells and a few inflammatory cells. Bony callus tissues were observed at the edge of defect area. The average cicatrization time of APBSC/BMG group was shorter than BMG group (P < 0.05). There were no obvious adverse reactions found during the treatment. APBSC/BMG has good biocompatibility, absorbability and bone induction in the process of bone defect healing. The effect of APBSC/BMG is better than BMG.

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