Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (3): 465-467.doi: 10.3969/j.issn.1673-8225.2011.03.021

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Preparation of low-molecular-weight hyaluronan liposomes and their percutaneous penetration

Zhang Wen-qiang1,2, Huang Yue-shan1   

  1. 1Biological Science and Engineering College, South China University of Technology, Guangzhou  510006, Guangdong Province, China
    2Research Institute of Tsinghua University in Shenzhen, Shenzhen  518057, Guangdong Province, China
  • Received:2010-08-07 Revised:2010-12-07 Online:2011-01-15 Published:2011-01-15
  • Contact: Huang Yue-shan, Doctor, Associate professor, Biological Science and Engineering College, South China University of Technology, Guangzhou 510006, Guangdong Province, China
  • About author:Zhang Wen-qiang★, Master, Biological Science and Engineering College, South China University of Technology, Guangzhou 510006, Guangdong Province, China; Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong Province, China yywenzi23@163.com

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Abstract:

BACKGROUND: Hyaluronic acid is a versatile polymer material, in practical applications, due to its large molecular weight, percutaneous absorption effect is not satisfied, the use of liposomes as a carrier can improve its transmission effect, with a good application prospect.
OBJECTIVE: To study the percutaneous penetration of the liposomes carrying low-molecular-weight hyaluronic acid.
METHODS: Low-molecular-weight hyaluronan liposomes were prepared through thin films. Orthogonal experiment was design, and percutaneous penetration was study by snake slough.
RESULTS AND CONCLUSION: The low-molecular-weight hyaluronan liposomes could enwrap more hyaluronic acid when the temperature is 35 ℃, the ratio of cholesterol and lecithin is 0.15∶1, the ratio of hyaluronic acid and lecithin is 0.03∶1, and the pH of hydration medium PBS is 7.5. Hyaluronic acid could penetrate the snake slough more easily when they were enwrapped by liposome, and the percutaneous penetration of hyaluronic acid was improved.

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