Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (53): 10021-10025.doi: 10.3969/j.issn.1673-8225.2010.53.034

Previous Articles     Next Articles

Effect and mechanism of salvia miltiorrhiza on flap ischemia-reperfusion injury

He Zhi, Qiu Shu-lin   

  1. Department of Burns and Plastic Surgery, People’s Hospital of Hebei Province, Shijiazhuang  050051, Hebei Province, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Qiu Shu-lin, Professor, Master’s supervisor, Department of Burns and Plastic Surgery, People’s Hospital of Hebei Province, Shijiazhuang 050051, Hebei Province, China qiushulin8229@sina.com.cn
  • About author:He Zhi★, Master, Physician, Department of Burns and Plastic Surgery, People’s Hospital of Hebei Province, Shijiazhuang 050051, Hebei Province, China modernhuatuo@163.com
  • Supported by:

    the Foundation for Science and Technology Research and Development in Hebei Province, No.09276102D-31*

PDF

348

Abstract:

BACKGROUND: The flap ischemia-reperfusion injury is a complex pathophysiological process, but the specific mechanism is not yet clearly. The traditional Chinese medicine Danshen (salvia miltiorrhizae) has a role to reduce ischemia reperfusion injury and the necrosis of skin flap after flap transplanting.
OBJECTIVE: To discuss the research progress of salvia miltiorrhizae on protects the flap from ischemia-reperfusion injury.
METHODS: Elsevier database and CNKI was retrieved by computer with key words of “salvia miltiorrhizae, flap, ischemia-reperfusion” to search papers published between January 1980 and April 2010. Related papers addressing medical dressings were selected. According to inclusion criteria, 50 literatures were selected in this study.
RESULTS AND CONCLUSION: The studies regarding salvia miltiorrhiza preventing and treat heart, liver, brain, kidney, intestines and other organs ischemia-reperfusion injury are more, which shows that salvia miltiorrhiza may be from the cell level, gene level and micro-circulation, through numbers of channels, varieties of mechanisms to reduce ischemia reperfusion injury. But the studies on salvia miltiorrhiza protecting the flaps ischemia-reperfusion injury are fewer, and the exact mechanism is not entirely clear. Thus, the protective effect of salvia miltiorrhiza to flaps’ ischemia-reperfusion injury need to be further explored.

CLC Number: