Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (49): 9298-.doi: 10.3969/j.issn.1673-8225.2010.49.041

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Effects of miRNA and Notch signaling pathway on cardiac development

Huang Feng, Zhou Sheng-hua, Pan Jia-yi, Bai Zhong-le, Wang Zhen-he   

  1. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha  410011, Hunan Province, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Zhou Sheng-hua, Doctor, Professor, Chief physician, Doctoral supervisor, Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China zhougqin@21cn.com
  • About author:Huang Feng☆, Studying for doctorate, Attending physician, Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China huangfeng3000@126.com

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Abstract:

BACKGROUND: miRNA has the functions of regulating cell proliferation and differentiation, promoting the development of organisms. Notch signaling pathway plays an important role in cell proliferation and differentiation, and the same in organ and organization development. Studies concerning miRNA and Notch signaling pathways in cardiac development and their relationship may provide new ideas in stem cell transplantation for treating certain heart diseases.
OBJECTIVE: To summarize the study progress of the roles that miRNA and Notch signaling pathway playing in cardiac development.
METHODS: We searched literary on the Google Scholar, PubMed database and ScienceDirect-Home website with the key words of “miRNA, Notch signaling pathway, cardiac development, stem cells”.
RESULTS AND CONCLUSION: miRNA has many biological functions in cardiac development such as regulation of cell proliferation and differentiation by adjusting target gene mRNA, or inhibiting its translation. Notch signaling pathway could determine the fate of cells and play an important role in cardiac normal development. Moreover, miRNA could induce embryonic stem cells differentiation into myocardial cells by regulating Dll1 receptor of the Notch signal. Grasping the mechanism and relation of miRNA or Notch signaling pathway playing in cardiac development, and how they induce stem cells differentiation into myocardial cells, could provide us with new intervention targets using stem cells to treat certain heart diseases.

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