Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (49): 9285-.doi: 10.3969/j.issn.1673-8225.2010.49.038

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Traditional Chinese medicine in stem cells study

Zhang Liang-deng 1,2, Yao Kui-wu 1, Wang Jie1   

  1. 1Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing  100053, China; 2School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, Beijing  100029, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Yao Kui-wu, Doctor, Associate chief physician, Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China yaokuiwu@yahoo.com.cn
  • Supported by:

     the Beijing Medical Health Science and Technology Association Program of Capital Medical Science Development Scientific Research Foundation, No. SF2007Ⅰ04*

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Abstract:

BACKGROUND: Stem cells are hot topic research in regenerative medicine. More and more literatures on traditional Chinese medicine (TCM) intervention in stem cell culture have been reported.
OBJECTIVE: To further explore the correlation of TCM to culture, induction, growth and differentiation of stem cells by reviewing and summarizing studies of stem cells intervention in TCM recent years.
METHODS: We searched experiments or clinical researches literatures of stem cells intervention in TCM through China National Knowledge Infrastructure and Chinese sci-tech periodical full-text database published from January 1991 to January 2010. The key words were “TCM” or “Chinese materia medica” and second key word “stem cells”. Then, TCM prescriptions, stem cells types, application value, affiliations and funds were extracted, for setting up a database and frequency analysis. 
RESULTS AND CONCLUSION: Totally 167 documents were retrieved, only 31 of which met the inclusion criteria. The usual therapies on stem cells intervention in TCM are that removing stasis and blood circulation, tonifying qi, nourishing kidney and replenish vital essence. There is regularity between TCM therapies and stem cells types. Famous and effective prescriptions and effective TCM components are widely used, especially TCM of notifying qi, removing stasis and blood circulation, nourishing kidney and replenish vital essence. TCM can improve mobilization, proliferation and differentiation of stem cells to repair injured tissues and organs. Fund increased year by year, mainly focused by National Nature Science Foundation of China and related researches have focused on developed regions. There is solid base of theory and clinic of targeted stem cells in TCM. Targeted stem cells in TCM would integrate regenerative thought with clinical thought of TCM, extend the harmony of yin and yang to the era of stem cells and regenerative medicine.

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