Abstract:

BACKGROUND: Allogeneic transfusion and transfusion-induced complications in total joint replacement have aroused increasing attention. Recently, the influence of acute normovolumic hemodilution (ANH) on hemodynamics and coagulation function has been understood in animal experiments, which can reduce incidence of thrombosis.
OBJECTIVE: To evaluate the effect of ANH on circulatory function and homoiostasis of perioperative period in patients undergoing total hip replacement.
METHODS: A total of 60 patients undergoing elective total hip replacement randomly divided into control and ANH groups, with 30 cases in each group, respectively injected with balanced solution and Voluven. The mean blood pressure (MBP), heart rate (HR) and central venous pressure (CVP) were continuously monitored throughout the operation. The values of blood clotting, arterial blood gas and blood routine were detected in two groups.
RESULTS AND CONCLUSION: Compared with control group, MAP was more stable in ANH group. The hemoglobin and hematocrit were significantly greater in 6 and 24 hours postoperatively in ANH group compared with control group (P < 0.01). The volume of allogeneic transfusion was lower in ANH group than the control group (P < 0.01). ANH is more effective and safer in patients undergoing total hip replacement with stable hemodynamics and few effects on homoeostasis. Moreover, ANH can reduce thrombosis.