Abstract:

OBJECTIVE: To evaluate the biocompatibility and biodegradability of tissue engineering material spinal cord anti-adhesion membrane.
METHODS: A computer search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI Database (www.cnki.net/index.htm) was performed by the first author using “biocompatibility; chitosan; spinal cord; biological materials” in English and in Chinese as key words. Articles related to the materials science, biocompatibility and application of the key words were included, those recently published or published in the authority journals were preferred in the same field. A total of 42 literatures were involved.
RESULTS: Prevention and reduction of epidural scar adhesion after spinal surgery have been a research focus. Anti-adhesion material implanted is the main method of preventing and reducing epidural scar adhesion. Ideal anti-adhesion materials should have good biocompatibility, no inflammatory response, no rejection; can effectively cover the surgical site, prevent fibrous tissue ingrowth, degrade for appropriate time, have no toxic side effects. Chitosan is a class of potential developing natural biological materials, and obtains more and more attention for the application in biomedical research.
CONCLUSION: Chitosan is a type of materials with good biocompatibility and can play a preventive role on epidural adhesion after laminectomy, and remarkably inhibit the epidural collagen proliferation and metabolism after laminectomy, thereby reducing the formation of scar tissue, has broad application prospects in tissue engineering research.