Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (39): 7277-7280.doi: 10.3969/j.issn.1673-8225.2010.39.014

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Biomechanical changes of tibial plateau fracture healing in rabbits

Wang Wei-bin, Han Da-cheng, Chen Jian-hai, Zhang Pei-xun, Wang Jing, Zhang Hong-bo, Jiang Bao-guo   

  1. Department of Orthopaedics and Traumatology, Peking University People’s Hospital, Beijing 100044, China
  • Online:2010-09-24 Published:2010-09-24
  • Contact: Jiang Bao-guo, Doctor, Professor, Department of Orthopaedics and Traumatology, Peking University People’s Hospital, Beijing 100044, China jiangbaoguo@vip.sina.com
  • About author:Wang Wei-bin☆, Doctor, Attending physician, Department of Orthopaedics and Traumatology, Peking University People’s Hospital, Beijing 100044, China wangweibin@bjmu.edu.cn 392354613@qq.com
  • Supported by:

    the National Basic Research Program of China (973 Program), No. 2005cb522604)*; the Foundation of Beijing Science and Technology Committee, No. ZOO05190041391*; the Science and Technology Development Program of National 11th Five-Year Plan, No. 2007BA104B06*

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Abstract:

BACKGROUND: Studies regarding the biomechanical changes during tibial plateau fractures healing are few.
OBJECTIVE: To evaluate the maximal loading and maximal point energy changes with or without screw fixation during the healing process of tibial plateau fractures in rabbits.
METHODS: A total of 39 New Zealand rabbits were used to establish models of tibial plateau fractures and fixed by screws. At selected time points after operation [0 (3 rabbits), 1, 2, 3, 4, 6 and 8 weeks (6 rabbits)], the tibial specimens were harvested and subjected to biomechanical testing. The maximum load of anti-compression at the medial tibial plateau and the energy to maximum in rabbits with or without fixing screws were recorded. Intact tibia specimens were measured as controls.
RESULTS AND CONCLUSION: The maximum load and the energy to maximum increased during the first stage and reached the peak at 4 weeks postoperatively compared with control group (P < 0.05), then recovered to normal levels at 8 weeks. The measured values of the two groups changed similarly. In the early healing process of tibial plateau fractures, the strength of fracture healing presented a single peak curve, and the screw fixation was efficient.

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