Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (39): 7268-7272.doi: 10.3969/j.issn.1673-8225.2010.39.012

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Influence of bone elongation speed on osteogenesis

Chang Fei, Yu Qing-wei, Liu Guang-yao, Wang Jin-cheng   

  1. Department of Orthopedics, Bethune Third Hospital of Jilin University, Changchun  130033, Jilin Province, China
  • Online:2010-09-24 Published:2010-09-24
  • Contact: Wang Jin-cheng, Doctor, Professor, Department of Orthopedics, Bethune Third Hospital of Jilin University, Changchun 130033, Jilin Province, China jinchengwang@hotmail.com
  • About author:Chang Fei☆, Doctor, Attending physician Department of Orthopedics, Bethune Third Hospital of Jilin University, Changchun 130033, Jilin Province, China ccfei_cn@hotmail.com
  • Supported by:

    the Doctoral Foundation of Ministry of Education, No. 20090061120081*; the New Teacher Scientific Research Foundation of Jilin University, No. 602959*

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Abstract:

BACKGROUND: Bone elongation is a complicated process that remains poorly understood. Elongation speed is a major factor that affects the bone consolidation. Further research could provide more information and help understand bone lengthening.
OBJECTIVE: To investigate the influence of elongation speed on distraction osteogenesis.
METHODS: Following osteotomy at the middle segment of rat left femur, the external frisket was installed for fixation. The lengthening protocol included a seven-day latency period, followed by an incremental lengthening of 0.5 mm/d or 1 mm/d for 2 weeks. The animals were sacrificed 21 days after the operation. Bone hardness and bone mineral density was determined. Histological examinations were also performed.
RESULTS AND CONCLUSION: No statistical difference was observed in bone mineral density and hardness between the 0.5 mm group and the 1 mm group on 21 days after the operation. Helix fibers were observed in 0. 5 mm/d group, while more straight fibers in 1 mm/d group were detected. No complication was observed in both groups. Results indicated that 1 mm/d elongation can accelerate the procedure, shorten the treatment time without further complications.

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