Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (39): 7238-7242.doi: 10.3969/j.issn.1673-8225.2010.39.005

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Finite element analysis of chitin in combination with autologous micromorselized bone in repairing bone defects

Shen Hong-tao1, Yan Jing-long2   

  1. 1 Second Department of Orthopedics, 2 Fourth Department of Orthopedics, First Hospital of Harbin Medical University, Harbin  150081, Heilongjiang Province, China
  • Online:2010-09-24 Published:2010-09-24
  • Contact: Yan Jing-long, Doctor, Professor, Doctoral supervisor, Fourth Department of Orthopedics, First Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
  • About author:Shen Hong-tao★, Master, Attending physician, Second Department of Orthopedics, First Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China baigesmw@yahoo.com.cn
  • Supported by:

     the National Natural Science Foundation of China, No.30371441*

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Abstract:

BACKGROUND: Chitin functions as scaffold, which enhances structures of autologous micromorselized bone, prevents its distribution out of implant bone bed, reduces bone loss and degrades along micromorselized bone osteogenesis.
OBJECTIVE: To explore the effects of autologous micromorselized bone in combination with chitin on repairing bone defects.
METHODS: A total of 20 adult hybrid dogs were selected to establish models of the lamina in lumbar defect, and randomly divided into 4 groups. The combination group was implanted with autologous micromorselized bone and chitin; autologous micromorselized bone group was implanted with autologous micromorselized bone alone; chitin group was implanted with chitin alone, while blank control group was not implanted. The defect-repairing capability of the 4 treatments was assessed by three-dimensional finite element analysis at 8 weeks.
RESULTS AND CONCLUSION: The displacement was greatest in chitin group, followed by autologous micromorselized bone group and then combination group. According to the theory that little displacement represents great rigidity, the rigidity of combination group was the greatest, followed by autologous micromorselized bone group and then chitin group. The chitin was a good carrier of the autologous micromorselized bone. The autologous micromorselized bone carried by chitin has more ability of repairing the bone defect compared with autologous micromorselized bone or chitin alone.

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