Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (26): 4787-4790.doi: 10.3969/j.issn.1673-8225.2010.26.009

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Huoxue Tongluo decoction in the prevention of lower extremity deep venous thrombosis following femoral head prosthetic replacement in the elderly patients

Jin Xiang1, Zhang Yun-shen1, Chen Jin-fei1, Ma Yong1, Wang Pei-min2, Dai Qing-sheng2, Shen Ji-rong2, Xu Jian-an2   

  1. 1Nanjing University of Chinese Medicine, Nanjing   210029, Jiangsu Province, China;
    2Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing   210029, Jiangsu Province, China
  • Online:2010-06-25 Published:2010-06-25
  • Contact: Ma Yong, Professor, Master’s supervisor, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China zhongyi-my@263.net
  • About author:Jin Xiang, Studying for doctorate, Associate chief physician, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China

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Abstract:

BACKGROUND: Artificial femoral head replacement has been commonly used in femoral intertrochanteric fracture in elderly patients. However, the incidence of postoperative deep vein thrombosis is high, especially prevalent in the lower extremities. Therefore, how to prevent and treat lower extremity deep venous thrombosis effectively has become a hot issue in the medical profession.

OBJECTIVE: To observe the effect of Huoxue Tongluo decoction on deep vein thrombosis following operation of comminuted femoral intertrochanteric fracture in elderly patients.

METHODS: A total of 38 elderly patients with comminuted femoral intertrochanteric fracture undergoing artificial femoral head replacement were randomly divided into two groups: Huoxue Tongluo decoction and low molecular weight heparin (LMWH) groups, which was respectively treated with Huoxue Tongluo decoction and subcutaneous injection of LMWH. Incision drainage volume, change of platelet count and prothrombin time of the patients in two groups were observed and compared. Deep vein thrombosis was examined with lower extremity vascular color Doppler.

RESULTS AND CONCLUSION: Incision drainage volume of Huoxue Tongluo decoction was less than the LMWH group (P < 0.05), but no differences were observed in platelet count between two groups (P > 0.05). Huoxue Tongluo decoction and LMWH significantly extended prothrombin time and partial thromboplastin time, but effect of LMWH was better than Huoxue Tongluo decoction (P < 0.05). There were both two cases of mild deep venous thrombosis in two groups, and Huoxue Tongluo decoction and LMWH played similar role in the prevention of deep venous thrombosis. Results show that Huoxue Tongluo decoction can prevent the occurance of lower extremity deep venous thrombosis after operation of comminuted femoral intertrochanteric fracture in elderly patients, and its efficacy is similar as LMWH. Moreover, it has good safety, and can be widely used in the clinic.

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