Abstract:

OBJECTIVE:To evaluate the biocompatibility of coronary artery stent implantation and explore the relationship between platelet activation and stent restenosis following coronary artery stent implantation.
METHODS: A computer-based online search of CNKI (1990/2009) and Pubmed database(1990/2009) was performed with the key words “coronary artery stent, platelet activation, biocompatibility” in Chinese and English. Articles related to biocompatibility and relationship between platelet activation and stent restenosis following coronary artery stent implantation were included. Meta analysis and repetitive studies were excluded.
RESULTS:Coronary artery stent implantation damages vessel wall and activates body immune response process. Growth factors and cytokines released from endothelial cells, platelet and inflammatory leukocyte promotes vascular smooth muscle cell proliferation, which contributes to restenosis. This study explored the relationship of platelet activation and in-stent restenosis and biocompatibility following stenting and prospected development of biodegradable stents.
CONCLUSION: Biodegradable stents could minimize possibility of restenosis, and protect from thrombosis, which bring hope for treating restenosis following stent implantation.on.