Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (13): 2345-2348.doi: 10.3969/j.issn.1673-8225.2010.13.017

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Effectiveness comparison between knee replacement and arthroscopic debridement combined sodium hyaluronate injection for knee osteoarthritis

Huang Liang-ku1, Chen Shi-rong1, Tang Jin2, Peng Li-hua2, Xu Tao3, Feng Qing-lin4   

  1. 1 Second Affiliated Hospital of Chongqing Medical University, Chongqing  400000, China; 2 Department of Orthopaedics, 3 Department of Anesthesiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing  400000, China; 4 Department of Neurosurgery, First Affiliated Hospital of Chongqing Medical University, Chongqing  400000, China
  • Online:2010-03-26 Published:2010-03-26
  • Contact: Chen Shi-rong, Professor, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
  • About author:Huang Liang-ku★, Studying for master’s degree, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China lovehlk2003@163.com

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Abstract:

BACKGROUND: Treatments for knee osteoarthritis (KOA) contain injecting sodium hyaluronate into the intra-articular or surgical arthroscopic debridement and artificial knee replacement. At present, most study concerning the treatment of osteoarthritis concentrates on effectiveness comparison between various individual therapies, which are few in combined therapy.
OBJECTIVE: To investigate the efficacy of treating KOA using knee replacement and arthroscopic debridement with intra-articular injection of sodium hyaluronate.
METHODS: Fifty-five KOA patients were collected, aged 50-83 years. The surgical methods were decided by patients following telling the advantages and disadvantages of each treatment. Patients in the joint group (n=23) were treated by arthroscopic debridement and intra-articular injection of sodium hyaluronate, once a week, for 5 successive weeks; those in the replacement group (n=32) received total knee replacement. All patients were followed-up for 6-30 months. The effectiveness of KOA treatment was evaluated by HSS knee scores prior to and after operation. 
RESULTS AND CONCLUSION: The comprehensive assessment showed, in the joint group, there were 8 excellent cases and 8 good cases with 70 % good rate; in the replacement group, there were 23 excellent cases and 7 good cases, with 94 % good rate. The therapeutic effect of the replacement group was superior to the joint group (P < 0.05). The knee joint activity, pain, and joint functions were improved significantly after operation, in particular in the replacement group.

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