Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (11): 2043-2047.doi: 10.3969/j.issn.1673-8225.2010.11.036

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Role of placenta-derived growth factor in vascular regeneration of ischemic cerebrovascular diseases

Wu Lei, Luo Yong   

  1. Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing Key Laboratory of Neurology, Chongqing   400016, China
  • Online:2010-03-12 Published:2010-03-12
  • Contact: Luo Yong, Doctor, Investigator, Doctoral supervisor, Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing Key Laboratory of Neurology, Chongqing 400016, China luoyong1998@163.com
  • About author:Wu Lei, Studying for master’s degree, Department of Neurology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing Key Laboratory of Neurology, Chongqing 400016, China wulei_19821982@163.com
  • Supported by:

    the Scientific Research Program of Traditional Chinese Medicine of Chongqing Health Bureau, No.2005-B-24*

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Abstract:

BACKGROUND: The effect of placenta-derived growth factor (PLGF) on promoting vascular regeneration remains uncertain. In studies of models with PLGF deletion, PLGF has been considered to play critical role in inducing angiogenesis.
OBJECTIVE: To summarize the research advances in effect of PLGF and its receptor in vascular regeneration and ischemic cerebral disease.
METHODS: A computer-based online search of Pubmed and CNKI was performed for relevant articles published between 1990 and 2009 with key words of “PLGF” in Chinese and “PLGF, angiogensis” Articles related with biological characteristics of PLGF and its roles in vascular regeneration and articles related with angiogenesis and PLGF expression after cerebral ischemia were selected. Repetitive articles were excluded.
RESULTS AND CONCLUSION: The role of PLGF and its receptor in vascular regeneration, mechanism of PLGF and its receptor to promote angiogenesis, vascular endothelial growth factor A, and the expression of PLGF and its receptor in brain after cerebral ischemia were introduced. PLGF can promote pathological angiogenesis, arteriogenesis, branch formation and hemopoietic progenitor cell mobilization. PLGF and its receptor play an important role in the angiogenesis of ischemic cerebral disease and display a good clinical prospect in the treatment of ischemic cerebral disease. However, the specific role and mechanism require further study.

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