Abstract:

BACKGROUND: The establishment of animal pulmonary hypertension models will promote the improvement of clinical diagnosis and treatment on pulmonary hypertension.
OBJECTIVE: To analyze and summarize the establishment of animal pulmonary hypertension models.
METHODS: The databases of PubMed and CNKI were retrieved with key words of “pulmonary hypertension and animal model”. Studies concerning the following aspects were included: using surgery method to prepare animal pulmonary hypertension models; using drug injection method to prepare animal pulmonary hypertension models; animal severe pulmonary hypertension model; pathophysiological comparison between animal models and pulmonary hypertension patients; and drug intervention on animal pulmonary models. 
RESULTS AND CONCLUSION: The methods for animal pulmonary hypertension models construction including: Surgical shunt, monoerotatine injection, chronically hypoxic and so on, in addition, the animal several severe pulmonary hypertension models which appeared at distal pulmonary artery neointimal lesion formation was reported. Through continuous improvement, they have provided insights into pathological cellular and molecular signaling pathways. However, how closely any of the models simulate to the cellular and molecular pathobiology of human pulmonary hypertension was poorly understood.