Abstract:

BACKGROUND: Along with the medicine development, the prevention and treatment of the atrophy of denervated skeletal muscle have made a remarkable progress, but the clinical curative effect is still not satisfied.
OBJECTIVE: To summarize the current status of the prevention and treatment methods of denervated skeletal muscle atrophy, and to find a more effective method for the prevention and treatment of the denervated of skeletal muscle atrophy.
METHODS: Using “denervation, muscle atrophy, treatment” in English for the search term, Medline database from January 1998 to January 2008 was retrieved. Using “denervation, muscle atrophy, treatment: in Chinese for the search term, the Chinese Journal Full-text Database from January 1998 to January 2008, Wanfang Database from January 1998 to January 2008, and Journal of Clinical Rehabilitation and Tissue Engineering Research from January 1998 to January 2008 were searched. Literature was limited to English and Chinese languages. The muscular endurance and contractile force, muscle wet weight of denervated nerve, and skeletal muscle repair served as the evaluation index. The studies on the micro-surgical procedures, physical therapy, biological and chemical therapies, gene therapy for the atrophy of denervated skeletal muscle were included. Except the above methods, other therapies to the denervated skeletal muscle atrophy were excluded.
RESULTS AND CONCLUSION: After peripheral nerve damage, the skeletal muscle is denervated and then inevitably atrophy occurs. Therefore, the exploration of prevention and treatment of denervated skeletal muscle atrophy has attracted the interests from many domestic and foreign scholars, will certainly become the important task and the research hot spot in the 21st century in the peripheral nerve domain. The microsurgery surgery, physiotherapy, biology and chemotherapeutics, gene therapy are the main effective prevention methods for the atrophy of denervated skeletal muscle. At present, this domain's research already presents the multiple perspectives and various tendencies. The prevention and treatment of denervated skeletal muscle atrophy has already given the pointed management, but in the improvement microcycle, but much works need to carry on in fields of improving microcirculation, preventing cell apoptosis, suppressing the collagen excessive growth, as well as adjusting myogenic regulatory factors expression using gene therapy method in the gene level, but also had the. Along with the tissue engineering, cell culture science, molecular biology, genetic engineering and so on, an unceasing development will be obtained regarding the prevention and treatment of denervated skeletal muscle atrophy.