Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (11): 2022-2025.doi: 10.3969/j.issn.1673-8225.2010.11.031

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Peroxisome proliferator-activated receptor-gamma coactivator 1 and skeletal muscle adaptation

Deng Lei1, Wang Song2, Niu Jie2   

  1. 1Department of Physical Education, Jiangsu Institute of Economic and Trade Technology, Nanjing   211168, Jiangsu Province, China;
    2Department of Military Education and Training, Basic College of the PLA University of Science and Technology, Nanjing   211101, Jiangsu Province, China
  • Online:2010-03-12 Published:2010-03-12
  • About author:Deng Lei, Associate professor, Department of Physical Education, Jiangsu Institute of Economic and Trade Technology, Nanjing 211168, Jiangsu Province, China dd588@vip.sina.com

Abstract:

BACKGROUND: An increase in activity of muscle contraction can induce transcription of a variety of signaling molecules to activate a large number of gene expression within the nucleus through proprietary signaling pathway.
OBJECTIVE: To review studies related the peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) and exercise induced skeletal muscle adaptations.
METHODS: A computer-based online search of Pubmed was performed for relevant English articles published from January 1995 to January 2009 with the keywords of “PGC1, skeletal muscle, exercise, adaptations”. The relevant articles about PGC-1 and exercise induced skeletal muscle adaptations were included, and repetitive contents were excluded. PGC1 and mitochondrial oxidative metabolism, and exercise-induced skeletal muscle adaptation and PGC1s changed served as the evaluation indicators.
RESULTS AND CONCLUSION: Of 57 collected articles, 34 were classified and sorted according to the criteria. Endurance training results in profound adaptations for skeletal muscle, including mitochondrial biogenesis, capillary density, and fiber composition. Transcription factors are highly dependent on coactivator molecules to regulate training physiologic adaptation processes. The majority of transcription factors target genes are involved in mitochondrial biogenesis and metabolism. These transcriptional patterns may provide a basic framework for understanding the integration of mitochondrial biogenesis and function with signaling events that exercise induced energetic properties. Post-transcription of PGC-1 alpha protein, there are a variety of protein modifications, with a variety of biological processes closely related to the possible adaptive mechanism of exercise-induced skeletal muscle.

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