Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (11): 1967-1970.doi: 10.3969/j.issn.1673-8225.2010.11.017

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Effects of fluorid on biomechanical parameters of the femur in young rats

Wu Tian-xiu1, Liao Jin-min2, Chen Yan2, Huang Lian-fang2, Chen Wen-shuang2   

  1. 1Department of Human Anatomy, Guangdong Medical College, Zhanjiang  524023, Guangdong Province, China;
    2Guangdong Key Laboratory for Research and Development of Natural Drugs,  Zhanjiang  524023, Guangdong Province, China
  • Online:2010-03-12 Published:2010-03-12
  • Contact: Liao Jin-min, Doctor, Professor, Master’s supervisor, Guangdong Key Laboratory for Research and Development of Natural Drugs, Zhanjiang 524023, Guangdong Province, China jinminliao@yahoo.com.cn
  • About author:Wu Tian-xiu, Master, Lecturer, Department of Human Anatomy, Guangdong Medical College, Zhanjiang 524023, Guangdong Province, China wutianxiu2005@163.com
  • Supported by:

    the Natural Science Foundation of Guangdong Province, No. 06301445*

Abstract:

BACKGROUND: Fluoride treatment of osteoporosis has been controversial. Literatures addressing the effect of fluoride on bone bio-mechanical parameters of femur in young rats are few.

OBJECTIVE: To study the effects of fluoride on bone biomechanical parameters of femur in young rats.

METHODS: Ninety 2-month-old SPF Sprague Dawley rats, half male and female, were randomly divided into 9 groups: control group (young, adult and long-time) and drug-administered group (young high-fluoride, young low-fluoride, adult high-fluoride, adult low-fluoride, long-term high-fluoride and long-term low-fluoride). Rats in the control group were orally administered with physiological saline, while in the drug-administered group were given orally with different dose fluoride at the corresponding times. After experiment, rats were sacrificed under anaesthesia. Three-point bending test was performed at the left femur. The effects of fluoride on maximum load and rigidity of femur were measured.

RESULTS AND CONCLUSION: Compared with young control group, the maximum load and the rigidity of femur in the young high-fluoride group were decreased by 13.18% and 13.61%, respectively (P < 0.05), which had no dramatically difference in the young low-fluoride group. Compared with long-term high-fluoride group, the maximum load and the rigidity of femur in the young high-fluoride were decreased by 17.22% and 17.17% (P < 0.05), which were obvious increased in the long-term low-fluoride group by 18.33% and 19.15%, respectively (P < 0.05). The maximum load and the rigidity of femur were strengthened in the adult high-fluoride and adult low-fluoride groups (P < 0.05). The results suggested that young rats are more sensitive to high-dose fluoride, which can reduce bone quality in rats. The negative effects on bone quality of rats were gradually displayed as the prolongation of the period of fluoride.

CLC Number: