Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (49): 9281-.doi: 10.3969/j.issn.1673-8225.2010.037

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Application of induced differentiation of bone marrow mesenchymal stem cells to retinal diseases

Zhang Ke-jian1, Liu Xue-zheng1, Hou Yang1, Zhang Ming-rui2   

  1. 1Department of Anatomy, Liaoning Medical University, Jinzhou  121001, Liaoning Province, China; 2Hospital of Stomatology Affiliated to Jilin University, Changchun  130021, Jilin Province, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Liu Xue-zheng, Doctor, Professor, Department of Anatomy, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China liuxuezheng168@vip.sina.com
  • About author:Zhang Ke-jian★, Studying for master’s degree, Department of Anatomy, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China kejianzhang88@163.com
  • Supported by:

    the Science and Technology Project of Jinzhou City, No. 0222121*

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Abstract:

BACKGROUND: Recent studies indicate that bone marrow mesenchymal stem cells (BMSCs) could differentiate into neuron-like cells, have the fusion with the original retina structure and can be part of the treatment of retinal degeneration. 
OBJECTIVE: To conclude and analyze biological characteristics of BMSCs and their clinical application in retinopathy. 
METHODS: China National Knowledge Infrastructure and PubMed Database were searched by computer for articles on research and application of BMSCs in retinopathy published from January 1995 to May 2010. The key words were “bone marrow mesenchymal stem cells, retina” or “retinopathy”. The related articles about BMSCs for retinopathy were included, and those published recently or in authorized journals in the same field were included. A total of 286 articles were primarily collected. In accordance with inclusion criteria, 29 articles were used for this review.
RESULTS AND CONCLUSION: BMSCs have the potential of differentiating into retina-like cells, and possibility of differentiating into retinal nerve cells to repair damaged retina. BMSCs can differentiate into retinal nerve cells, help damaged retina to repair. BMSCs transplantation in retina can be used to treat retinal degeneration. However, at present, it is not ideal to differentiate into retinal cells following BMSCs transplantation. The mechanism of induced differentiation remains unclear. Thus, the pathway of retinal transplantation and posttransplanted outcomes require further investigations.

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