Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (26): 4751-4754.doi: 10.3969/j.issn.1673-8225.2010.026.001

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Design and construction of loading equipment suitable to manipulation for cell mechanics

Ma Hui-sheng1, Zhang Hong2, Yan Jun-tao2, Shen Guo-quan2   

  1. 1Department of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan   750004, Ningxia Hui Autonomous Region, China;
    2Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai   200437, China
  • Online:2010-06-25 Published:2010-06-25
  • Contact: Zhang Hong, Doctor, Associate chief physician, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • About author:Ma Hui-sheng, Doctor, Associate professor, Department of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China madoctor@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30300462*

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Abstract:

BACKGROUND: Studies on the action mechanisms of manipulation mostly focus on the field in soft tissue, bone joint, nerve, and blood vessel. There are few reports on cytological level.
OBJECTIVE: To design one kind of loading equipment suitable to manipulation for cell experiment in vitro to provide novel pathway and method for effective researches in cytological level.
METHODS: Vascular endothelial cells distribution in vessel wall was simulated. Human umbilical vein endothelial cells (HUVECs) were planted into elastic cultivated tube which was regarded as model of blood vessel. Then elastic sponge materials with elasticity coefficient similar to muscle were used to simulate the tissues around the vessels and blood vessel models were placed in the simulated tissue. Rolling manipulation was operated on the surface to stimulate HUVECs to simulate in vivo mechanical environment to the largest extent.
RESULTS AND CONCLUSION: A loading model for cell mechanics in vitro suitable to manipulation was established. The establishment of this model provides a new way to investigate the mechanism of manipulation action in the cytobiology.

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