Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (2): 313-316.doi: 10.3969/j.issn.1673-8225.2010.02.029

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Research progress in the treatment of avascular necrosis of the femoral head with bone marrow mesenchymal stem cells transplantation  

Qiu Wei 1, 2 , Meng Zeng-dong 1, 2    

  1. 1 Department of Orthopaedics, Kunming Medical University Affiliated Kunhua Hospital, Kunming  650032, Yunnan Province, China; 2 Department of Orthopaedics, The First People’s Hospital of Yunnan Province, Kunming  650032, Yunnan Province, China  
  • Online:2010-01-08 Published:2010-01-08
  • About author:Qiu Wei★, Studying for master’s degree, Department of Orthopaedics, Kunming Medical University Affiliated Kunhua Hospital, Kunming 650032, Yunnan Province, China; Department of Orthopaedics, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China tlger111@163.com

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Abstract:

BACKGROUND: Avascular necrosis of the femoral head occurs in the hip joints at high load-bearing areas, it is a special form of aseptic bone necrosis. Bone marrow-derived mesenchymal stem cells may have an excellent repair effect for the necrosis of femoral head.
OBJECTIVE: To understand bone marrow mesenchymal stem cell transplantation for treatment of early avascular necrosis of the femoral head, and to lay a foundation for further study.
METHODS: Taking avascular necrosis of femur head, femur head necrosis, osteonecrosis, bone marrow mesenchymal stem cells, mesenchymal stem cells, multipotent stem cells in English as search terms, Pubmed database from January 2000 to April 2009 was retrieved; Taking avascular necrosis and bone marrow mesenchymal stem cells in Chinese as search terms, CNKI database from January 1989 to April 2009 was searched. Literatures were limited to English and Chinese languages. Inclusive criteria: Study of the biological characteristics and functions of bone marrow mesenchymal stem cells, the etiology and pathology of avascular necrosis of femoral head, bone marrow mesenchymal stem cell transplantation for treatment of avascular necrosis; Exclusive criteria: duplication of documents.
RESULTS AND CONCLUSION: More than 800 literatures were screened out by computer search, according to inclusive and exclusive criteria, 38 documents of which were involved for analysis. Marrow mesenchymal stem cells can differentiate into chondrocytes, osteocytes and dipocytes under suitable cultural condition. With the development of stem cell engineering, marrow mesenchymal stem cell transplantation becomes an effective method for repairing osteonecrosis. This article describes the cause and the pathology of avascular necrosis of the femoral head, analyzes the theory basis for the treatment of avascular necrosis of the femoral head with marrow mesenchymal stem cell, and verifies its effect through comparing both animal and clinical experiments of this aspect at home and abroad, with the hope of seeking a better treatment.

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