Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (36): 6825-6827.doi: 10.3969/j.issn.1673-8225.2010.36.040

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Effects and possible molecular mechanisms of Schwann cells for the repair of peripheral nerve damage   

Gao Wei, Shao Shui-jin, Hu Lin-na, Liu Yan-xiang   

  1. Shanghai University of Traditional Chinese Medicine, Shanghai  201203, China
  • Online:2010-09-03 Published:2010-09-03
  • Contact: Shao Shui-jin, Doctor, Professor, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • About author:Gao Wei★, Studying for master’s degree, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China gaowei529982@ yahoo.com.cn
  • Supported by:

     the Key Subject Construction Program of Education Committee of Shanghai City, No. J50301*; the Second Phase Construction Program of Great Master Lineage Research Engineering of Shanghai University of Traditional Chinese Medicine*

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Abstract:

BACKGROUND: The recovery of neural function following peripheral nerve damage has been the focus. Schwann cells have very important effects on the recovery of neural function.
OBJECTIVE: To summarize the effect and possible molecular mechanism of Schwann cells in promoting neural function recovery.
METHODS: The databases of China National Knowledge Infrastructure, VIP and Offshore Vessel Inspection Database were searched for articles about peripheral nerve damage published from January 1993 to January 2010. The key words were “Schwann cells, peripheral nerve, nerve regeneration and review”, which were searched by inputting in titles and abstracts. The articles addressing Schwann cells effects on peripheral nerve damage were selected. The literatures in the same field that published recently or in authorized journals were included. There were 256 articles after the initial survey. Finally, 24 articles concerning action mechanism of Schwann cells according to inclusion criteria were included for this review. 
RESULTS AND CONCLUSION: Schwann cells affect the damaged peripheral nerve through various channels and promote poor functional recovery. How to accelerate proliferation of Schwann cells will be a breakthrough point for the recovery of neural function. By synthesizing various factors, electroacupuncture for peripheral nerve injury will have a better future.

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